For Physicians

Cancer

For further information, please refer to the following scientific papers.

INTERNATIONAL JOURNAL OF CANCER/2024

Ligorio, Francesca et al. “Adding fasting-mimicking diet to first-line carboplatin-based chemotherapy is associated with better overall survival in advanced triple-negative breast cancer patients: A subanalysis of the NCT03340935 trial.” International journal of cancer vol. 154,1 (2024): 114-123. doi:10.1002/ijc.34701

CANCER RESEARCH/2024

Raucci, Franca et al. “Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia.” Cancer research vol. 84,7 (2024): 1133-1148. doi:10.1158/0008-5472.CAN-23-0295

CANCERS/2024

Buono, Roberta et al. “Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival.” Cancers vol. 15,24 5870. 16 Dec. 2023, doi:10.3390/cancers15245870

EUROPEAN JOURNAL OF CANCER/2022

Ligorio, Francesca et al. “Exceptional tumour responses to fasting-mimicking diet combined with standard anticancer therapies: A sub-analysis of the NCT03340935 trial.” European journal of cancer (Oxford, England : 1990) vol. 172 (2022): 300-310. doi:10.1016/j.ejca.2022.05.046

CELL REPORTS/2022

Cortellino, Salvatore et al. “Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects.” Cell reports vol. 40,8 (2022): 111256. doi:10.1016/j.celrep.2022.111256

AGING CELL/2022

Rahmani, Jamal et al. “Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.” Aging cell vol. 21,2 (2022): e13540. doi:10.1111/acel.13540

CANCER DISCOVERY/2022

Vernieri, Claudio et al. “Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer.” Cancer discovery vol. 12,1 (2022): 90-107. doi:10.1158/2159-8290.CD-21-0030

CANCERS/2021

Valdemarin, Francesca et al. “Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment.” Cancers vol. 13,16 4013. 9 Aug. 2021, doi:10.3390/cancers13164013

NATURE/2020

Caffa, Irene et al. “Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression.” Nature vol. 588,7839 (2020): E33. doi:10.1038/s41586-020-2957-6

BREAST CANCER RESEARCH AND TREATMENT/2021

Lugtenberg, Rieneke T et al. “Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013-14) trial.” Breast cancer research and treatment vol. 185,3 (2021): 741-758. doi:10.1007/s10549-020-05991-x

NATURE COMMUNICATIONS/2020

de Groot, Stefanie et al. “Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial.” Nature communications vol. 11,1 3083. 23 Jun. 2020, doi:10.1038/s41467-020-16138-3

NATURE COMMUNICATIONS/2020

Di Tano, Maira et al. “Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers.” Nature communications vol. 11,1 2332. 11 May. 2020, doi:10.1038/s41467-020-16243-3

Nature Review Cancer / 2018
Fasting and cancer: molecular mechanisms and clinical application.

BMC CANCER / 2018
The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

Stephan P. Bauersfeld1, Christian S. Kessler1,2, Manfred Wischnewsky3, Annette Jaensch2, Nico Steckhan1, Rainer Stange1,2, Barbara Kunz2, Barbara Brückner4, Jalid Sehouli5 and Andreas Michalsen1,2

JOP. Journal of the Pancreas / 2018
Long-Term Outcomes of the Treatment of Unresectable (StageIII- IV) Ductal Pancreatic Adenocarcinoma Using Metabolically Supported Chemotherapy (MSCT): A Retrospective Study

CELL PRESS / 2018
Starvation, Stress Resistance, and Cancer

SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

PLOS|BIOLOGY / 2017

Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy

ELSEVIER / 2017
Protective effects of short-term dietary restriction in surgical stress and chemotherapy

SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

AACR / 2016
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

BIOMED CENTRAL / 2016
Safety and feasibility of fasting in combination with platinum based chemotherapy

CELL PRESS / 2016
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

ELSEVIER / 2016
Growth factors, aging and age-related diseases

BMC CANCER / 2015
The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study

Stefanie de Groot1, Maaike PG Vreeswijk2, Marij JP Welters1, Gido Gravesteijn2, Jan JWA Boei2, Anouk Jochems1, Daniel Houtsma3, Hein Putter4, Jacobus JM van der Hoeven1, Johan WR Nortier1, Hanno Pijl5 and Judith R Kroep1

IMPACT JOURNALS / 2015
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition

IMPACT JOURNALS / 2015
Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

ELSEVIER / 2013
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression

DISCOVER / 2013
A small group of Ecuadorians with rare genetic disorder could hold a key to cancer and other age-related illness.

NATIONAL INSTITUTE OF HEALTH / 2013
Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer

SCIENCE TRANSLATIONAL MEDICINE / 2012
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

ELSEVIER / 2012
Starvation, detoxification, and multi drug resistance in cancer therapy

PLOS / 2012
Fasting Enhances the Response of Glioma to Chemo and Radiotherapy

C Lee and VD Longo / 2011
Fasting vs dietary restriction in cellular protection and cancer treatment:from model organisms to patients

JOVE / 2011
Video ArticleStudying Age-dependent Genomic Instability using theS. cerevisiae Chronological Lifespan Model

CANCER RESEARCH / 2010
Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fastingand Improve Chemotherapeutic Index

JCB / 2009
Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Pol-dependent mechanism

IMPACT AGING / 2009
Fasting and cancer treatment in humans: A case series report

PNAS / 2008
Starvation-dependent differential stress resistanceprotects normal but not cancer cells againsthigh-dose chemotherapy

PERSPECTIVES / 2008
Turning anti aging genes against cancer

JCB / 2008
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system

ELSEVIER / 2007
A simple model system for age-dependent DNA damage and cancer

Neurodegenerative Diseases

For further information, please refer to the following scientific papers.

CELL REPORTS/2022

Rangan, Priya et al. “Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models.” Cell reports vol. 40,13 (2022): 111417. doi:10.1016/j.celrep.2022.111417

THE JOURNAL OF NEUROSCIENCE  / 2017
Behavioral/CognitiveBrain Structure and Function Associated with YoungerAdults in Growth Hormone Receptor-Deficient Human

CELL PRESS / 2016
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple SclerosisSymptoms

CELL PRESS / 2016

AGING CELL / 2013
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer’s disease mouse model

AGING CELL / 2013

The Scientific World JOURNAL / 2010
Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Non dividing Cells: from Yeast to the Mammalian Brain

NEUROENDOCRINOLOGY / 2009
Progesterone Influence on Neurite Outgrowth Involves Microglia

CELL PRESS / 2008
SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

ELSEVIER / 2004
Progressive changes in regulation of apolipoproteins E and J in glial cultures during postnatal development and aging 

ELSEVIER / 2004
Reversible age impairments in neurite outgrowth by manipulations of astrocytic GFAP

THE JOURNAL OF NEUROSCIENCE / 2002
Peroxynitrite Mediates Neurotoxicity of Amyloid-Peptide1–42- andLipopolysaccharide-Activated Microglia

ENDOCRINOLOGY / 2002
Estradiol (E2) Enhances Neurite Outgrowth byRepressing Glial Fibrillary Acidic Protein Expression and Reorganizing Laminin

AMERICAN MEDICAL ASSOCIATION / 2002
Genetics of Aging and Diseases

JOURNAL OF NEUROCHEMISTRY / 2000
Reversible Inactivation of Superoxide-Sensitive Aconitase inAb1–42-Treated Neuronal Cell Lines

EXPERIMENTAL NEUROLOGY / 1999
Variations of Synaptotagmin I, Synaptotagmin IV, and SynaptophysinmRNA Levels in Rat Hippocampus during the Estrous Cycle

Autoimmune diseases

For further information, please refer to the following scientific papers.

THE JOURNAL OF NUTRITION/2024

Hadžić, Kajs et al. “Restrictive diets have a beneficial impact on dextran sodium sulfate-induced colitis in male mice.” The Journal of nutrition vol. 154,1 (2024): 121-132. doi:10.1016/j.tjnut.2023.11.005

CELL REPORTS/2019

Rangan, Priya et al. “Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology.” Cell reports vol. 26,10 (2019): 2704-2719.e6. doi:10.1016/j.celrep.2019.02.019

Nature Review Cancer / 2018
Fasting and cancer: molecular mechanisms and clinical application.

BMC CANCER / 2018
The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

Stephan P. Bauersfeld1, Christian S. Kessler1,2, Manfred Wischnewsky3, Annette Jaensch2, Nico Steckhan1, Rainer Stange1,2, Barbara Kunz2, Barbara Brückner4, Jalid Sehouli5 and Andreas Michalsen1,2

JOP. Journal of the Pancreas / 2018
Long-Term Outcomes of the Treatment of Unresectable (StageIII- IV) Ductal Pancreatic Adenocarcinoma Using Metabolically Supported Chemotherapy (MSCT): A Retrospective Study

CELL PRESS / 2018
Starvation, Stress Resistance, and Cancer

SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

PLOS|BIOLOGY / 2017

Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy

ELSEVIER / 2017
Protective effects of short-term dietary restriction in surgical stress and chemotherapy

SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

AACR / 2016
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

BIOMED CENTRAL / 2016
Safety and feasibility of fasting in combination with platinum based chemotherapy

CELL PRESS / 2016
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

ELSEVIER / 2016
Growth factors, aging and age-related diseases

BMC CANCER / 2015
The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study

Stefanie de Groot1, Maaike PG Vreeswijk2, Marij JP Welters1, Gido Gravesteijn2, Jan JWA Boei2, Anouk Jochems1, Daniel Houtsma3, Hein Putter4, Jacobus JM van der Hoeven1, Johan WR Nortier1, Hanno Pijl5 and Judith R Kroep1

IMPACT JOURNALS / 2015
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition

IMPACT JOURNALS / 2015
Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

ELSEVIER / 2013
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression

DISCOVER / 2013
A small group of Ecuadorians with rare genetic disorder could hold a key to cancer and other age-related illness.

NATIONAL INSTITUTE OF HEALTH / 2013
Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer

SCIENCE TRANSLATIONAL MEDICINE / 2012
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

ELSEVIER / 2012
Starvation, detoxification, and multi drug resistance in cancer therapy

PLOS / 2012
Fasting Enhances the Response of Glioma to Chemo and Radiotherapy

C Lee and VD Longo / 2011
Fasting vs dietary restriction in cellular protection and cancer treatment:from model organisms to patients

JOVE / 2011
Video ArticleStudying Age-dependent Genomic Instability using theS. cerevisiae Chronological Lifespan Model

CANCER RESEARCH / 2010
Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fastingand Improve Chemotherapeutic Index

JCB / 2009
Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Pol-dependent mechanism

IMPACT AGING / 2009
Fasting and cancer treatment in humans: A case series report

PNAS / 2008
Starvation-dependent differential stress resistanceprotects normal but not cancer cells againsthigh-dose chemotherapy

PERSPECTIVES / 2008
Turning anti aging genes against cancer

JCB / 2008
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system

ELSEVIER / 2007
A simple model system for age-dependent DNA damage and cancer

Diabetes & Obesity

For further information, please refer to the following scientific papers.

DIABETOLOGIA/2024

van den Burg, Elske L et al. “Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial.” Diabetologia, 10.1007/s00125-024-06137-0. 28 Mar. 2024, doi:10.1007/s00125-024-06137-0

NATURE COMMUNICATIONS/2024

Brandhorst, Sebastian et al. “Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk.” Nature communications vol. 15,1 1309. 20 Feb. 2024, doi:10.1038/s41467-024-45260-9

THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM/2022

Sulaj, Alba et al. “Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study.” The Journal of clinical endocrinology and metabolism vol. 107,8 (2022): 2167-2181. doi:10.1210/clinem/dgac197

BMC ENDOCRINE DISORDERS/2020

van den Burg, Elske L et al. “Correction to: Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes.” BMC endocrine disorders vol. 20,1 164. 4 Nov. 2020, doi:10.1186/s12902-020-00635-z

CELL  / 2017
Fasting-Mimicking Diet Promotes Ngn3-Drivenb-Cell Regeneration to Reverse Diabetes

SCIENCE TRANSLATIONAL MEDICINE / 2011
Growth Hormone Receptor Deficiency Is Associatedwith a Major Reduction in Pro-Aging Signaling,Cancer, and Diabetes in Humans

Scientific Articles

For further information, please refer to the following scientific papers.

  1. Starvation, Stress Resistance, and Cancer – Cell Press 2018  PDF

  2. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer
    and Chemotoxic Resistance in Aged Mice – Scientific Reports 2017  PDF

  3. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy – Plos 2017  PDF

  4. Protective effects of short-term dietary restriction in surgical stress and chemotherapy – Elsevier 2017  PDF

  5. Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions – American Association for Cancer Research 2016  PDF

  6. Safety and feasibility of fasting in combination with platinum-based chemotherapy – BioMed Central  2016  PDF

  7. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity – Cancer Cell 2016  PDF

  8. Fasting and Caloric Restriction in Cancer Prevention and Treatment – 2016   PDF

  9. Growth factors, aging and age-related diseases – Elsevier 2016  PDF

  10. Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition – Oncotarget 2015  PDF

  11. Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models – Oncotarget 2015  PDF

  12. Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression – Elsevier 2013  PDF

  13. A small group of Ecuadorians with a rare genetic disorder could hold a key to cancer and other age-related illness – Discover 2013  PDF

  14. Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer – 2013  PDF

  15. Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy – Science Translational Medicines 2012  PDF

  16. Starvation, detoxification, and multi-drug resistance in cancer therapy – Elsevier 2012  PDF

  17. Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy – Plos 2012  PDF

  18. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients – NPG 2011  PDF

  19. Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model – Jove 2011  PDF

  20. Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index – Cancer Research 2010  PDF

  21. Fasting and cancer treatment in humans: A case series report – Impact Aging 2009  PDF

  22. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy – PNAS  PDF

  23. Turning anti-ageing genes against cancer – Nature Reviews 2008  PDF

  24. Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system –  The Journal of Cell Biology 2008  PDF

  25. A simple model system for age-dependent DNA damage and cancer – Elsevier 2007  PDF

Contact us

Longevity Technology Institute at Fondazione Valter Longo

Via Borgogna, 9, 20122 Milano | Tel. 02.25138307 | info@europeanlongevityinstitute.org